Based on integrated transcriptomic and functional analysis, they showed that peripheral blood MCL cells cultured in the presence of CD40-L and cytokine stimuli displayed cellular (proliferation, survival) and molecular (NF-kB pathways, Bcl-2 family, secretome) profiles similar to the ones seen in lymph-node-resident MCL cells, emphasizing the relevance of the model and the role of CD40-L expressing T cells for tumor survival [28,33,36]. The gene discussed is NFKB1; the disease is mantle cell lymphoma.