In particular, among the underlying molecular aberrations characterizing melanoma and its etiology, the most frequent molecular changes involve genetic mutations of CDKN2A, CCND1, CDK4, MITF, c-KIT and MC1R genes; dysregulation of mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)-Akt pathways; aberrant p53, STAT3, NRF2, NFκB, cadherin, and Wnt signaling pathways; and epigenetic alterations [8,9,10,11,12]. The gene discussed is STAT3; the disease is melanoma.