CD8+ T cells: Pearce et al. [189] showed that metformin promotes the generation of CD8+ T cells and increases protective immunity against lymphoma in mice, while Ekawa et al. [190] demonstrated that metformin enhances tumor infiltration of CD8+T cells, protects them from apoptosis, and promotes the production of IL-2, TNFα, INFγ. This evidence concerns the gene CD8A and neoplasm.