BCL2 and glioblastoma: Shi et al. reported that combination treatment of glioblastoma cells with miR-125b-2 and temozolomide potently increased cancer cells apoptosis through activation in the mitochondrial pathway by targeting APAF-1, CASPASE-3, BAX, BCL-2, and poly-ADP-ribose polymerase (PARP) [145].