KIT and DOG1 are used as highly sensitive diagnostic markers for GIST, but they are expressed also in other mesenchymal tumors relevant for GIST differential diagnosis, such as synovial sarcomas, leiomyomas, leiomyosarcomas, angiosarcomas, Ewing sarcomas, malignant peripheral nerve sheath tumors, and schwannomas [28]. The gene discussed is ANO1; the disease is leiomyoma.