In addition to being the primary oncogene in GISTs, KIT (CD117) is a highly sensitive diagnostic marker, being expressed in >95% of cases, but it is rarely also expressed in other abdominal or GI tumors relevant for differential diagnosis such as intestinal metastatic melanoma, colorectal adenocarcinoma, angiosarcoma, and extraskeletal Ewing sarcoma [7,8]. This evidence concerns the gene KIT and colorectal adenocarcinoma.