sEV produced by breast cancer cells in hypoxia contain increased amounts of ILK and subsequent interaction of these sEV with normal mammary cells activates NFκB signaling, resulting in inflammatory cytokine release and activation of mitochondrial dynamics leading to increased cell motility, and, in 3-dimensional (3D) mammary acini, to dysregulated proliferation, reduced apoptosis and promotion of EMT [45]. Here, ILK is linked to breast cancer.