For example, in the context of gliobastoma multiforme (GBM), radioresistant p53-wildtype, but not p53-mutant GBM cells are sensitized to radiotherapy in the context of genetic depletion of PINCH or ILK, identifying an ILK-dependent therapeutic vulnerability to radiation treatment in these cells [73]. This evidence concerns the gene LIMS1 and glioblastoma.