NET-DNA-mediated stimulation of breast cancer cells resulted in activation of a NET-CCDC25-ILK signaling axis resulting in the activation of the migration/invasion promoting Rho family GTPases, Rac, and cdc42, while depletion of CCDC25, ILK, or β-parvin reduced Rac1/cdc42 activation (Figure 3) [33]. Here, CCDC25 is linked to breast cancer.