Inactivation of ILK in postnatal endothelial cells (ECs) reduces β-catenin levels in vitro and in vivo, leads to modulation of lymphoid enhancer binding factor 1 (LEF1) expression in the retinal vasculature and results in the perturbation of retinal angiogenesis, similar to phenotypes observed in models and patients with FEVR [16]. This evidence concerns the gene LEF1 and Familial exudative vitreoretinopathy.