Overexpression of ILK in colorectal cancer cells results in activation of NF-kB and promotion of EMT, while depletion of ILK expression or inhibition of NF-kB suppresses EMT in these cells, indicating a role of ILK-mediated NF-kB signaling in colon cancer [51,63]. The gene discussed is NFKB1; the disease is malignant colon neoplasm.