ILK signaling is involved in mediating an interleukin-6 (IL-6)/STAT3/NF-κB feed-back loop that drives ILK expression and IL-6 production by AML cells, and ILK activity and expression are associated with the production of IL-1, which is enriched in AML and induces the growth of LSCs. This evidence concerns the gene ILK and acute myeloid leukemia.