For example, histologically “low-grade” astrocytoma, IDH-wildtype (IDH-wt) and EGFR-amplification, TERT-promotor mutation, or combined gain of chromosome 7 and loss of chromosome 10, can be considered as glioblastoma (GBM), and consequently as WHO Grade 4 [10]. The gene discussed is EGFR; the disease is glioblastoma.