METTL3 has been found to guarantee the stability of hexokinase 2 (HK2) and solute carrier family 2 member 1 (SLC2A1) via an m6A-insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)/3-dependent pathway, contributing to the tumorigenesis of colorectal cancer (CRC) [41]. The gene discussed is IGF2BP2; the disease is colorectal cancer.