Moreover, m1A methylation in a subset of tRNA is upregulated by TRMT6/TRMT61A, resulting in an increment of peroxisome-proliferator-activated receptor delta (PPARδ) translation, which in turn stimulates cholesterol synthesis and activates hedgehog signaling to promote the oncogenesis of HCC [59]. This evidence concerns the gene PPARD and hepatocellular carcinoma.