MBD2 and cancer: We describe the structure of m6A, m1A, and m6Am in eukaryotic cells; explicitly state how corresponding enzymes including methyltransferases (writers), demethylases (erasers), and readers modify RNAs in a dynamic manner, with focus on m6A-, m1A-, and m6Am regulated RNAs in the oncogenesis and metastasis of cancer; and present our perspective on their therapeutic potential in cancer (Figure 1).