Additionally, the overexpression of TIM-3 restricts T-cells’ responses, and levels of circulating and tumor-infiltrating CD8+PD-1+TIM-3+ cells, which produced significantly less IFN-γ than CD8+PD-1−TIM-3− cells, were increased in CRC patients [14]. This evidence concerns the gene HAVCR2 and colorectal carcinoma.