Of note, Li et al., showed that TIM-3 is also highly expressed on γδ T cells, which represent a low population of CD3+CD4−CD8− T cell populations in the TME, in CRC patients, and attributed reduction in perforin/granzyme B production in γδ T cell subtypes to TIM-3 expression [44]. The gene discussed is HAVCR2; the disease is colorectal carcinoma.