So as to determine whether the knockdown of GSN and PRDX4 can suppress tumorigenesis in vivo, a nude mouse model of CRC cells xenograft (n = 6) was implanted subcutaneously into the DLD-1 cells transfected with the control shRNA (Control shRNA) or the GSN shRNA and PRDX4 shRNA (Figure 8). This evidence concerns the gene PRDX4 and colorectal carcinoma.