The molecular classification is further subdivided into luminal A (ER+, PR+ and HER2-), Luminal B (ER+, PR+ and HER2+), HER2-enriched (ER-, PR- and HER2) and basal-like (triple negative breast cancer ER-, PR- and HER2-) [2]. This evidence concerns the gene ESR1 and triple-negative breast carcinoma.