With promising preclinical support [109,110,111,112], the efficacy of PARPi in prostate cancer is currently being investigated in combination with other agents such as anti-androgens [113,114,115], immunotherapeutics [116], chemotherapy [117], radiotherapy [118], and ATR (ataxia-telangiectasia and Rad3-related) protein inhibitors [119]. Here, ATR is linked to Familial prostate cancer.