Tumour microenvironment (TME) contains several immunosuppressive molecules such as vascular endothelial growth factor (VEGF), cyclooxygenase (COX)-2, interleukin (IL)-6, IL-10, transforming growth-factor-beta (TGF- β), stemcell factor-1, and macrophage colony-stimulating factor (M-CSF) which all inhibit antigen presentation. This evidence concerns the gene VEGFA and neoplasm.