FCGR3A and neoplasm: ADCC is promoted by binding the crystallizable (Fc) region of a mAb to the crystallizable fragment receptor (FcR) of the NK cell (specifically CD16 or FcyRIII), thereby releasing cytokines (such as granzymes, perforin, IFN-a or TNF-b) which will, in turn, induce tumour cell death.