Among them, significantly altered genes were: GBM1: up-regulated genes: RYR1, HS6ST2, and C14orf132, down-regulated genes: TACSTD2, VAMP8, and BPIFA1; JHH520: up-regulated genes: PAWR, TIMP3, and HOXB7, down-regulated genes: ABCG2, TSACC, and PYY; BTSC233: upregulated genes: NCAN, SHC2, and NF1, downregulated genes: SDK1, TFPI2, and NBDY. Furthermore, KEGG pathway analysis showed that these differentially expressed genes (DEGs) were highly associated with pathways ranging from metabolism to cancer (Figure 4C). This evidence concerns the gene SHC2 and cancer.