TIGIT and neoplasm: Further, genes associated with an enhanced effector state (e.g., ADGRE5, GNLY, CD82, CD7 and several granzymes) as well as genes associated with T cell (pre-)exhaustion and tumor-reactive features, such as HAVCR2, LAG3, PDCD1, TIGIT, and ENTPD1 (CD39), were significantly higher in GPR56-positive T cells.