CTLA4 and ovarian carcinoma: For instance, the treatment of PD-1 antibody Nivolumab, PD-L1 antibody Avelumab, PD-1 antibody Pembrolizumab, and CTLA-4 blocking antibody MDX-CTLA4 only yielded objective response rates (ORR) up to 15% in epithelial ovarian cancer (EOC) [5,6,7,8].