Analysis of the differentially expressed genes (DEGs) of the GPR56-positive and GPR56-negative cytotoxic CD8 T cells, terminally exhausted CD8 T cells, TH17 cells, proliferative T cells, regulatory T cells, and T helper cells revealed that, across multiple immune cell subtypes, the GPR56-positive population presented significantly higher expression of genes associated with cytotoxic/(pre-)exhausted/tumor-reactive gene signatures (Figure 1C, highlighted in orange). This evidence concerns the gene CD8A and neoplasm.