GAPDH and cancer: Figure 2 shows that these compounds did not affect GAPDH activity in normal fibroblasts (Figure 2a), likely for their differential membrane permeability as compared to cancer cells, while AXP-3009 and AXP-3019 significantly inhibited GAPDH in PANC-1 (Figure 2b) and MIA PaCa-2 (Figure 2c) PDAC cell lines. All compounds were then tested as inhibitors of the cellular proliferation of normal fibroblasts (Figure 2d), PANC-1 cells (Figure 2e), and MIA PaCa-2 cells (Figure 2f).