Despite a recent surge in the literature of single cell analyses that demonstrate the existence of TAMs which synchronously express signatures from both the M1 and M2 macrophage clusters [54], TAMs and TANs are classically divided into two subtypes: on the one hand, M1 and N1 secrete IFN-γ and IL-12, potentiating the effector compartment of the cellular immunity, evading tumor growth; on the other hand, the M2 and N2 phenotypes, which are associated with the secretion of IL-4, IL-10 and TGF-β, induce an Th2 immunologic response [50,55,56]. This evidence concerns the gene TGFB1 and neoplasm.