NFKB1 and cancer: Apart from inherited genetic predisposition, novel prognostic biomarkers have also been established, including proteins involved in the DNA damage response (ATR and ATM), cell death regulation (Beclin-1, BNIP3, HDAC-2, and PARP-1), immune function (BTNL9, PD-1, and PD-L1), genes of the NF-κB pathway (c-Rel, p50, p53, p65, and RelB) receptors (EphA1 and EphA5), cancer stem cell markers (nestin and ABCB5), antioxidant response (PRDX3), kinase signaling (PLK-1), insulin sensitizing (adiponectin), and spermatogenesis (SPANX-C) [9].