In murine models, ablative doses of radiation led to not only significant local CD8+ T cell infiltration that is accompanied by the reduction in myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), but also prominent distant tumor eradication in a CD8+ T-cell-dependent manner that requires DC-induced T cell priming [31,32]. Here, CD8A is linked to neoplasm.