TSPO and central nervous system cancer: Additionally, a direct comparison of [18F]GE-180 and [18F]FET uptake parameters in HGG patients indicated that IDH-wt gliomas showed significantly elevated [18F]GE-180 uptake compared to IDH-mutant gliomas [42], while [18F]FET uptake did not differ with the IDH-mutational status, therefore, reinforcing the suitability of TSPO PET in tumor classification.