These studies, together with recent evidence showing that the CXCR2-CXCL2-IL8 signaling has a similar effect on BMECs to VEGF/VEGFR [88], suggest that the inhibition of IL-8 may be an effective way to control and/or block damage to the endothelial barrier and prevent cancer progression. The gene discussed is CXCL8; the disease is cancer.