In particular, it has been shown that GBM-associated BMECs present a lower expression of VE-cadherin (CD144)—a TJ protein that plays an important role in the integrity of the BBB—as well as other TJs proteins, such as claudin-1, claudin-5 and occludin, compared to normal BMECs [50,51]. The gene discussed is CDH5; the disease is glioblastoma.