Importantly, PVT1, a non-coding oncogene, neighbors the MYC oncogene (File S8), with both genes known to be amplified in cancer [39], and the medulloblastoma samples harboring the observed PVT1 fusions belong to the Group 3 medulloblastoma subtype, characterized by MYC amplifications [40]. Here, MYC is linked to medulloblastoma.