Mechanistically, PLOD2 genetic depletion or minoxidil-mediated PLOD2 inhibition resulted in the formation of more “mature” collagen networks, characterized by increased prevalence of higher molecular weight collagen I species (dimers and trimers) and the deposition of more linear fibrillar collagen fibers in the sarcoma ECM [49]. This evidence concerns the gene PLOD2 and sarcoma.