Moreover, consistent with previously recognized relationships among tumor-initiating potential, chemoresistance, and metastatic colonization, P4HA1 knockdown or P4HA inhibition increased the chemosensitivity of TNBC cells, both in vitro and in vivo, and reduced the incidence of metastases in docetaxel-treated mice [140]. The gene discussed is P4HA1; the disease is neoplasm.