LRAT and colorectal cancer: For example, using murine models of liver-metastatic pancreatic and colorectal cancer, Bhattarcharjee and colleagues demonstrated that collagen I produced by both lecithin-retinol acyltransferase (Lrat+) and αSMA+ hepatic stellate cell-derived CAFs (HSC-CAFs) physically impeded the growth of metastatic lesions [73].