CD8A and neoplasm: Further, in support of an important role for CD73 in regulating anti-CLL tumor immunity, and consistent with the fact that CD8+ effector memory T cells (TEM) have been shown to restrain CLL progression [22], loss of CD73 was also associated with a significant increase in CD8+ TEM/TCM (Figure 4B and Figure S2E,F) and in IFN-γ production in male Eμ-TCL1tg/wt mice (Figure 4C and Figure S2G).