These constructs exhibited an increased expression of markers of tumor invasion and drug resistance (matrix metalloproteinase-2 and -9 [MMP2, MMP9], vascular endothelial growth factor receptor-2 [VEGFR2], and O6-methylguanine-DNA methyltransferase [MGMT]) when compared to solely U118-printed fibers. This evidence concerns the gene MMP2 and neoplasm.