Our observation that blocking the CBP/β-catenin interaction could lead to downregulated integrin α5β1 expression (Figure 5C) suggested that there may be a positive feedback loop between expression of integrin α5β1 and Wnt/β-catenin signaling, culminating in an aggressive phenotype observed in metastatic NPC. The gene discussed is CREBBP; the disease is nasopharyngeal carcinoma.