CD4 and neoplasm: TIGIT was overexpressed in C4 [49]/C9-CTLA [73] CD4 T cell clusters, C5 and C6 [49]/C4-GZMK [73] CD8 T cell clusters, NSCLC tumor B cells, and suppressive tumor Tregs of CD4-C9CTLA cells vs. other tumor-infiltrating Tregs of CD4-C8-FOXP3 cells [73].