Consistent with the role of Hsp90 in promoting HIF-1α and Akt stability, 80 μM and 160 μM cordycepin treatment significantly decreased protein levels of HIF-1α, Akt, ERK, and EGFR in ADA-low (92.1, MM28, Omm1) uveal melanoma cell lines, but not in those with high ADA (MP46 and MP38; Figure 5E; Supplemental Figure S3B,C). Here, HIF1A is linked to uveal melanoma.