Other molecular events suspected to facilitate latent infection, and thus contribute to carcinogenesis, include hypermethylation of specific genes (e.g., RASSF1A and BLU), deactivation of p16, deactivation of lactoferrin, and upregulation of cyclin D1 production [13,145,146]. This evidence concerns the gene RASSF1 and disease arising from reactivation of latent virus.