First, we analyzed several potential markers such as BIRC5, CDH11, EPCAM, KRT18, SPP1, TIMP2, UPK2, TRPA1, TRPC1, TRPC3, TRPC6, TRPV6, TRPM4, TWIST1, TNC, VEGFA, VIM, and ZEB1 disclosed as related to the BC primary tumor in studies published back to 2010. The gene discussed is SPP1; the disease is breast cancer.