Interestingly, it was discovered that SNPs rs4877831 and rs7867504 in hCNT3 were heavily correlated with early severe overall hematological toxicity, and rs4877831 and rs7867504 in hCNT3 and rs760370 in hENT1 were heavily correlated with late severe leukopenia. This evidence concerns the gene SLC28A3 and Decreased total leukocyte count.