Similarly, Zhang et al. verified that 62.1% of patients had a heterogeneous HER2 status between the primary tumor and CTC, and that the median PFS of the CTC HER2-positive patients was significantly longer than for the CTC HER2-negative patients (8.5 versus 3.5 months; p < 0.001) [18]. Here, ERBB2 is linked to neoplasm.