Interestingly, upregulation of miR-1 has been shown to decrease the levels of Bcl-2 in several cancers, including breast, prostate, lung, and colorectal cancers [51,52,53,54], and recently, Chen et al. have discovered the direct miR-1 binding site from the Bcl-2 3′UTR region [52]. The gene discussed is BCL2; the disease is cancer.