The significantly enriched signaling pathways in the lymphoma cells of the Granta-519 MCL tumors in response to the DPN treatment included the regulation of I-κΒ kinase/NF-κB signaling, EMT, cell adhesion, vasculogenesis, the lymphocyte apoptotic process, and the regulation of lymphocyte proliferation. The gene discussed is NFKB1; the disease is lymphoma.