After we discovered a novel type of adherens junction involving cis-E:N-cadherin heterodimers in the hepatocytes of embryonic and adult liver that also stably characterizes hepatocellular adenoma and carcinoma [32], we were interested in investigating E- and N-cadherin in the embryonically related cells of the biliary tract and pancreas as well as in derived tumors of the pancreatobiliary system. Here, CDH2 is linked to hepatocellular adenoma.