The significant up-regulation observed with different immune markers, CD45, CD3, CD4, CD8, and CD56, revealed the evident immune cell infiltration in tumors (Figure 8), which was one more favorable proof of the PD-1/PD-L1 blockade as a main mechanism in the CAM assay, allowing the tumor to grow in this immune-competent model. The gene discussed is CD4; the disease is neoplasm.