Specifically, CD80 molecules can restrain the IFN-γ-mediated upregulated expression of PD-L1 and thus, solve the dilemma of T-cell suppression, while transduced MHC II molecules, owing to the lack of an MHC II-associated invariant chain (Ii), can bind atypical tumor peptides and facilitate antigen presentation via non-conventional intracellular trafficking patterns [99,102]. This evidence concerns the gene CD274 and neoplasm.