NR1H4 and adenoma: In addition, FXR expression is greatly reduced in FAP patients and in tumors of ApcMin/+ mice spontaneously developing intestinal neoplasia [38,39], and Fxr deficiency in APCMin/+ mice results in increased adenoma size and number and is associated with a higher prevalence of tumors in azoxymethane-induced tumorigenesis [35,36].