In line with this, Fxr ablation increases susceptibility to chemically-induced colorectal carcinogenesis associated to inflammation [35], while constitutive activation of FXR in colon cancer cells injected in a xenograft model is able to suppress colonic epithelium proliferation and induce a pro-apoptotic gene network, [36]. The gene discussed is NR1H4; the disease is malignant colon neoplasm.