Our findings further strengthen the indication of FXR-FGF19-based therapies in the clinical management of chronic intestinal inflammation and CRC in patients with concomitant dysregulation of BA homeostasis, possibly due to unhealthy eating patterns leading to intestinal dysbiosis and comorbidities, such as obesity and type 2 diabetes. The gene discussed is NR1H4; the disease is obesity due to melanocortin 4 receptor deficiency.