EZH2 and esophageal squamous cell carcinoma: Through sponging miR-101 (as shown in ESCC), it is also likely that XIST overexpression may increase the levels of EZH2, a protein that plays a critical role in ATC [87] and whose overexpression in this malignancy is supported by epigenetic mechanisms involving miRNAs and lncRNAs, as previously reported [83,88].