Among the circRNAs involved in TC, it is worth mentioning hsa_circ_0058124 that shows oncogenic activity promoting PTC cell proliferation, tumorigenicity, tumor invasion, and metastasis by modulating miRNA-218-5p, which targets the NUMB endocytic adaptor protein (NUMB) gene, whose expression is critical for the fulfillment of asymmetric division in stem cells. The gene discussed is NUMB; the disease is neoplasm.