The hierarchical clustering revealed a group of proteins that have previously been reported to be expressed at elevated levels in ovarian cancer serum samples, including: CA125 (MUC16), HE4, MSLN, MK, KLK8, KLK11, NECT4, FOLR1, as well as KLK13, KLK14, and IL6 [3,26,27,28,29,30,31,32,33,34,35]. This evidence concerns the gene MSLN and ovarian cancer.