This transition allows for epithelial-like tumor cells to alter gene expression, such as decreasing epithelial proteins, including E-cadherin, claudin and occludin, while increasing mesenchymal proteins such as vimentin (VIM), N-cadherin and fibronectin (FN1), allowing them to survive after losing contact from adjacent cells and the basement membrane [15]. The gene discussed is FN1; the disease is neoplasm.