MSX1 and plasma cell myeloma: In addition, our laboratory recently demonstrated that selection for resistance to HYD-1, the linear derivative, in myeloma cell lines selected for a compromised cell-adhesion-mediated drug-resistant phenotype (CAM-DR) and that HYD-1 and MTI-101 are more potent in inducing cell death in specimens derived from myeloma patients that have relapsed in therapy compared to newly diagnosed samples [10].