Therefore, given that FAK inhibition will regulate the Hippo-YAP pathway, the same study tested FAK inhibitors (FAKi), VS-4718 (PND-1186) and PF562771, and observed in vitro that UM cells showed a dose-dependent sensitivity to these molecules, and that FAKi inhibits YAP-dependent UM tumour growth. This evidence concerns the gene PTK2 and neoplasm.