Two growth factors, PDGF-AA and PDGF-BB strongly increased in prostate cancer patients before therapy (3925 pg mean with 2367–5484 pg 95% CI and 13,332 pg mean with 8892–17,772 pg 95% CI in patients before treatment versus 1019 pg mean with 628.4–1410 pg 95% CI and 3865 pg mean with 2755–4974 pg 95% CI in healthy controls for PDGF-AA and PDGF-BB, respectively) (Figure 8A,B). Here, TEAD1 is linked to Familial prostate cancer.