Furthermore, IHC staining of cell proliferation marker protein Ki67 (Figure 6B) and cell apoptosis marker cleaved caspase-3 (Figure 6C) showed that TIV and PEM monotherapy cohorts inhibited tumor cell proliferation (decreased 0.65-fold and 0.51-fold vs. control, respectively) and promoted tumor cell apoptosis (increased 14.1-fold and 13.3-fold vs. control, respectively). The gene discussed is CASP3; the disease is neoplasm.