Sylvanie Surget et al. reported that p53 directly regulates DR5 gene expression, but not that of DR4, by increasing caspase-8 recruitment in myeloma [32], suggesting that AF8c selectively activates caspase-8 by increasing p53-mediated caspase-8 recruitment, thereby selectively inducing apoptosis. This evidence concerns the gene TNFRSF10A and plasma cell myeloma.