CALR and neoplasm: To investigate the regulatory mechanism underlying the chondroprotection, we first evaluated a group of tumor-suppressing proteins such as heat shock protein 90 beta (Hsp90ab1), calreticulin (Calr), histone H4 (H4), polyubiquitin C (Ubc), and enolase 1 (Eno1), all of which were commonly enriched in iTSC-derived CMs in our previous studies [17,19,23].