The latter is based on the observation that, in 15 cases of IDCp with concurrent low-grade invasive carcinoma analyzed with next-generation sequencing and immunohistochemistry for PTEN and ERG, IDC showed activation in the MAPK/PI3K pathway and a discordant PTEN/ERG status with the adjacent low-grade carcinoma [24]. This evidence concerns the gene PTEN and invasive carcinoma.