ANXA4 and colonic neoplasm: We also found that the experimental diet significantly down-regulated the expression of both ANXA4 (two-fold) and ANAXA2 (three-fold), which belong to the family of calcium-regulated phospholipid-binding proteins, as well as samll heat shock protein, namely, HSP27 (3-fold) whose higher abundance in colonic tissue was associated with increased proliferation, migration and invasion of colon cancer cells [45,46].