After gavage of COS to Wistar rats fed a high-fat diet for three weeks, Wang et al. [37] found that COS had a beneficial regulatory effect on lipid abnormality induced by the HFD, which improved the plasma lipoprotein profile by reducing VLDL TGs, increasing HDL-C and decreasing apoB-containing particles; the potential of COS in anti-atherosclerosis is worth further study. The gene discussed is APOB; the disease is atherosclerosis.