In addition, calgranulin-C, a protein secreted by activated neutrophils and monocytes/macrophages, and myeloperoxidase (MPO) activities increase in the mucosa of the duodenum and colon of dogs with CIE, and MPO also increases in the ileum and cecum. This evidence concerns the gene S100A12 and congenital non-bullous ichthyosiform erythroderma.